TSH receptor 抗体
Quick Overview for TSH receptor 抗体 (ABIN118959)
抗原
See all TSH receptor (TSHR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes the Human thyroid stimulating hormone (TSH) receptor binding to an extracellular domain. The epitope has been mapped to aa 379-384 (2).
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Affinity Chromatography on Protein G
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免疫原
- External domain of Human TSH receptor Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the NS1/AG4.1 myeloma cell line.
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亚型
- IgG2a
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anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 21-253) antibody
TSHR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 501-600) antibodyTSHR 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 648-740) antibodyTSHR 适用: 人, 小鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 201-300) antibodyTSHR 适用: 人, 小鼠 ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 28-245) antibodyTSHR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (C-Term) antibodyTSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (N-Term) antibodyTSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibodyTSHR 适用: 人 ELISA, IHC, StM, Coat 宿主: 小鼠 Monoclonal TSHRA-1402 unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibodyTSHR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TSHRB-1405 unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (Internal Region) antibodyTSHR 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow cytometry: use 10 μL of 1/100-1/1,000 diluted antibody to label 10^6 cells in 100 μL. Immunohistochemistry on frozen and paraffin sections (does not require protein digestion pre- treatment nor antigen retrieval using heat treatment prior to staining of paraffin sections). Histology positive control: Thyroid gland. Immunoprecipitation. Western blotting (1/1,000). According to customer information, this antibody has been used successfully on a peptide microarray (2). Not Suitable for ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.09 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
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别名
- Thyrotropin Receptor / TSHR
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背景
- Thyrotropin Receptor, a Glycoprotein Hormone Receptor, plays a central role in controlling thyroid cell metabolism. The TSH receptor can interact with both TSH and autoantibodies against the TSH receptor (thyroid-stimulating immunoglobulins, TSI). Mutations in the receptor are the cause for hyperthyroidism such as gestational hyperthyroidism (hypersensitivity to chorionic gonadotropin) and Grave's disease (autoimmune hyperthyroidism). Multiple isoforms of the thyrotropin receptor are produced by altervative splicing. The thyrotropin receptor has been reported in adipose, adrenal, brain, eye, heart, kidney, skin, thymus, and thyroid. ESTs have been isolated from brain, placenta, and thyroid libraries.Synonyms: LGR3, TSH-R, TSH-receptor, Thyroid-stimulating hormone receptor
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基因ID
- 7253
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NCBI登录号
- NP_000360
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UniProt
- P16473
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途径
- Thyroid Hormone Synthesis
抗原
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