VCAM1 抗体
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北京 101111
Quick Overview for VCAM1 抗体 (ABIN118837)
抗原
See all VCAM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody recognises Human VCAM-1, a 110 kDa molecule whose ligand is VLA-4. The antigen is expressed on activated endothelial cells and some tissue macrophages, bone marrow fibroblasts and myoblasts. Cross reactivity to Porcine CD106 has been reported.
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纯化方法
- Affinity Chromatography on Protein A.
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亚型
- IgG1
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应用备注
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Immunohistochemistry on frozen tissues. ELISA. Immunoprecipitation. Flow cytometry (1/10 - 1/50). This antibody inhibits cellular adhesion mediated by VCAM-1. Removal of sodium azide is recommended prior to use in fuctional assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.09 % Sodium Azide as preservative and 0.1 % BSA as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
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别名
- CD106 / VCAM1
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背景
- CD106 (known as VCAM1) is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells.Synonyms: INCAM-100, L1CAM, V-CAM 1, VCAM-1, Vascular cell adhesion protein 1
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基因ID
- 7412
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NCBI登录号
- NP_001069
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UniProt
- P19320
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途径
- Carbohydrate Homeostasis
抗原
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