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CD161 抗体

KLRB1 适用: 小鼠 FACS, IP, CyTox 宿主: 小鼠 Monoclonal PK136 unconjugated
产品编号 ABIN118295
发货至: 中国
  • 抗原 See all CD161 (KLRB1) 抗体
    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
    适用
    • 48
    • 15
    • 5
    • 3
    • 2
    • 2
    小鼠
    宿主
    • 43
    • 17
    小鼠
    克隆类型
    • 42
    • 18
    单克隆
    标记
    • 25
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    • 2
    • 2
    • 1
    • 1
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    • 1
    • 1
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    This CD161 antibody is un-conjugated
    应用范围
    • 40
    • 24
    • 11
    • 10
    • 10
    • 8
    • 5
    • 4
    • 2
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Cytotoxicity Test (CyTox)
    特异性
    This antibody (clone PK136) recognises the NK1.1 cell surface antigen. Although previously thought to recognise only CD161c, recent data has shown that the PK136 antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by PK136 appears to be even more complex, as only some CD161b positive strains are labelled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. This antibody is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. The antibody has also been used for in vivo depletion of NK cells and in vitro activation of NK cells.
    交叉反应 (详细)
    Species reactivity (tested):Mouse.
    纯化方法
    Affinity Chromatography on Protein A
    免疫原
    Spleen and bone marrow cells from CE mice. Spleen cells from immunised (C3H x BALB/c) FI Hybrid were fused with cells of the Sp2/0 - Ag14 myeloma cell line.
    克隆位点
    PK136
    亚型
    IgG2a
    Top Product
    Discover our top product KLRB1 Primary Antibody
  • 应用备注
    Flow Cytometry: use 10 μL of 5-10 μg/mL diluted antibody to label 1 x 10^6 cells in 100 μL. Immunoprecipitation. Cytotoxic Assays: 1-10 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
    别名
    CD161 / KLRB1 (KLRB1 产品)
    别名
    NKR-P1 antibody, KLRB1 antibody, 4930431A04Rik antibody, Gm4696 antibody, Klrb1g antibody, Klrb6 antibody, Ly-55 antibody, Ly55 antibody, NKR-P1G antibody, Nkrp-1e antibody, Nkrp1g antibody, CD161 antibody, CLEC5B antibody, NKR antibody, NKR-P1A antibody, NKRP1A antibody, hNKR-P1A antibody, Klrb1d antibody, Klrb1f antibody, Nkr-p1e antibody, killer cell lectin like receptor B1 antibody, killer cell lectin-like receptor subfamily B member 1 antibody, killer cell lectin-like receptor subfamily B, member 1 antibody, KLRB1 antibody, Klrb1 antibody
    背景
    NK1.1 is a cell surface glycoprotein encoded by members of the NKR-P1 gene family. In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc.Synonyms: C-type lectin domain family 5 member B, CLEC5B, HNKR-P1a, Killer cell lectin-like receptor subfamily B member 1, NKRP1A, Natural killer cell surface protein P1A
    基因ID
    3820
    NCBI登录号
    NP_002249
    UniProt
    Q12918
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