CD161 抗体
Quick Overview for CD161 抗体 (ABIN118293)
抗原
See all CD161 (KLRB1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- SM067A (Clone PK136) recognises the Mouse NK1.1 cell surface antigen also known as CD161. Although previously thought to recognise only CD161c, recent data has shown that the PK136 antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by PK136 appears to be even more complex, as only some CD161b positive strains are labelled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. PK136 is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. The antibody has also been used for in vivo depletion of NK cells and In Vitro activation of NK cells.
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无交叉反应
- 大鼠, 人
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交叉反应 （详细）
- Species reactivity (tested):Mouse
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纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Spleen and bone marrow cells from CE mice
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亚型
- IgG2a
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anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) (AA 73-188) antibody
KLRB1 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) antibodyKLRB1 适用: 人, Non-Human Primate FACS, WB, IHC (fro) 宿主: 小鼠 Monoclonal HP-3G10 unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) antibody (PE)KLRB1 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal 10-78 PE
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) (AA 67-225) antibodyKLRB1 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4C6A11 unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) (AA 151-225) antibodyKLRB1 适用: 人, 大鼠 ELISA 宿主: 兔 Polyclonal unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) antibodyKLRB1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) antibodyKLRB1 适用: 大鼠 FACS, WB, IP, IHC (fro), RIA 宿主: 小鼠 Monoclonal 10-78 unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) antibody (FITC)KLRB1 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal 10-78 FITC
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) antibodyKLRB1 适用: 大鼠 FACS, WB, IP, IHC (fro), RIA 宿主: 小鼠 Monoclonal 10-78 unconjugated
anti-Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1) (AA 73-140) antibodyKLRB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow Cytometry: use 10 μL of 5-10 μg/mL diluted antibody to label 1x10^6 cells in 100 μL. Complement dependent lysis 1-10 μg/mL (see Ref.4). In vivo depletion of NK cells (see Ref.4). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, without preservatives
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储存液
- Without preservative
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注意事项
- Dilute only prior to immediate use. Avoid cycles of freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
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别名
- CD161 / KLRB1
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背景
- NK1.1 is a cell surface glycoprotein encoded by members of the NKR-P1 gene family. In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc.Synonyms: C-type lectin domain family 5 member B, CLEC5B, HNKR-P1a, Killer cell lectin-like receptor subfamily B member 1, NKRP1A, Natural killer cell surface protein P1A
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基因ID
- 3820
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NCBI登录号
- NP_002249
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UniProt
- Q12918
抗原
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