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ITGB1 抗体

Cited in 1 publication. This anti-ITGB1 antibody is a 小鼠 单克隆 antibody detecting ITGB1 in FACS. Suitable for 人.
产品编号 ABIN1177328
发货至: 中国
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Quick Overview for ITGB1 抗体 (ABIN1177328)

抗原

See all ITGB1 抗体
ITGB1 (Integrin beta 1 (ITGB1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This ITGB1 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)

克隆位点

HUTS-21
  • 纯化方法

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    过滤

    0.2 μm filtered

    内毒素水平

    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

    亚型

    IgG2a kappa
  • 限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1.0 mg/mL

    缓冲液

    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

    储存液

    Azide free

    储存条件

    4 °C

    储存方法

    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • García-Gila, Cabañas, García-Pardo: "Analysis of the activation state of alpha4beta1 integrin in human B cell lines derived from myeloma, leukemia or lymphoma." in: FEBS letters, Vol. 418, Issue 3, pp. 337-40, (1998) (PubMed).

  • 抗原

    ITGB1 (Integrin beta 1 (ITGB1))

    别名

    CD29

    背景

    Reacts with the 130 kDa integrin beta1 subunit, CD29, that is expressed following cell activation as a heterodimeric complex with one of nine distinct alpha subunits, comprising the very late activation antigen (VLA) subfamily of adhesion receptors. The HUTS-21 beta1 epitope is weakly expressed on resting lymphocytes, but is upregulated by TPA, Ca++ ionophore, or another CD29 antibody, TS2/16. This upregulation is Mn++ dependent and not supported by other divalent cations such as Ca++ and/or Mg++. The VLA receptors have a broad cellular distribution and interact with ligands like VCAm-1 and MAdCAM-1 during cell adhesion. They also interact with extra-cellular matrices including collagen, laminin, fibronectin and others. HUTS-21 antibody enhances adherence of TPA-activated lymphocytes to fibronectin.
    Synonyms: Integrin beta1 Chain

    途径

    Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome
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