Integrin alpha 1 抗体
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Quick Overview for Integrin alpha 1 抗体 (ABIN1177273)
抗原
See all Integrin alpha 1 (ITGA1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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过滤
- 0.2 μm filtered
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内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
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免疫原
- Rat Emulsified Lewis Rat Glomeruli Cells
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亚型
- IgG2 lambda
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 72, Issue 3, pp. 367-75, (1995) (PubMed).
: "Identification of collagen and laminin receptor integrins on murine T lymphocytes." in: European journal of immunology, Vol. 24, Issue 9, pp. 2000-5, (1994) (PubMed).
: "VLA proteins in the integrin family: structures, functions, and their role on leukocytes." in: Annual review of immunology, Vol. 8, pp. 365-400, (1990) (PubMed).
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: "Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 72, Issue 3, pp. 367-75, (1995) (PubMed).
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- Integrin alpha 1 (ITGA1)
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别名
- CD49a
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背景
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The Ha31/8 antibody reacts with the 180-kDa integrin alpha1 chain (CD49a), which is a transmembrane glycoprotein that non-covalently associates with the integrin beta1 subunit (CD29) to form the alpha1beta1 (complex known as VLA-1). VLA-1 has been reported to be expressed on activated T cells, monocytes, smooth muscle cells, and endothelial cells. It is a receptor for collagen and laminin. The Ha31/8 monoclonal antibody is specific for both rat and mouse CD49a. It has been reported that Ha31/8 antibody can block VLA-1-mediated binding of rat cells to collagen.
Synonyms: Integrin alpha1 chain -
途径
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex
抗原
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