ITGB1 抗体
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- 抗原 See all ITGB1 抗体
- ITGB1 (Integrin beta 1 (ITGB1))
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适用
- 小鼠
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宿主
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Armenian Hamster
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克隆类型
- 单克隆
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标记
- This ITGB1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)
- 品牌
- BD Pharmingen™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- 免疫原
- Purified mouse VLA-4
- 克隆位点
- HM BETA 1-1
- 亚型
- IgG2 lambda
- Top Product
- Discover our top product ITGB1 Primary Antibody
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- 应用备注
- Reported applications include immunoprecipitation and in vitro inhibition (in combination with a mAb to mouse CD11a) of T-cell proliferative responses to anti-CD3e mAb 145-2C11 (Cat. no. 553057) and allogeneic cells. We recommend our immunohistochemistry formulation of purified HM beta1-1 mAb (Cat. No. 550530) for immunohistochemical staining (IHC) of rat tissues. For IHC of mouse tissues, we recommend the use of Purified Rat anti-Mouse CD29 mAb 9EG7 formulated for immunohistochemistry application (Cat. No. 550531).
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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Identification and functional characterization of mouse CD29 with a mAb." in: International immunology, Vol. 7, Issue 5, pp. 835-42, (1995) (PubMed).
: "Expression of a novel integrin beta 1 chain epitope and anti-beta 1 antibody-mediated enhancement of fibronectin binding are dependent on the stage of T cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 5, pp. 2125-33, (1995) (PubMed).
: "Recognition of murine integrin beta 1 by a rat anti-stromal cell monoclonal antibody." in: Hybridoma, Vol. 13, Issue 5, pp. 409-16, (1995) (PubMed).
: "Temporal expression of VLA-2 and modulation of its ligand specificity by rat glomerular epithelial cells in vitro." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 69, Issue 6, pp. 690-702, (1994) (PubMed).
: "Highly restricted expression of a stromal cell determinant in mouse bone marrow in vivo." in: The Journal of experimental medicine, Vol. 176, Issue 4, pp. 927-35, (1992) (PubMed).
: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, (1990) (PubMed).
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Identification and functional characterization of mouse CD29 with a mAb." in: International immunology, Vol. 7, Issue 5, pp. 835-42, (1995) (PubMed).
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- 抗原
- ITGB1 (Integrin beta 1 (ITGB1))
- 别名
- CD29 (ITGB1 产品)
- 背景
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The HMbeta1-1 antibody reacts with the 130-kDa integrin beta1 chain (CD29). CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin-alpha chains. With alpha1 through alpha6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with alphav (CD51), it forms alphavbeta1 integrin. It also associates with the integrin alpha7 alpha8, and alpha9 chains in non-lymphoid tissues. As a result, CD29 has a broad tissue distribution, including lymphocytes, endothelia, smooth muscle, epithelia, and oocytes. This hamster mAb to a mouse leukocyte antigen has been observed to crossreact with similar populations of rat leukocytes. Source of the immunogen was purified mouse VLA-4 (alpha4beta1, CD49d/CD29).
Synonyms: Itgb1, Integrin beta-1, Fnrb, gpIIa, VLA-4 subunit beta - 途径
- Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome
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