(12 references)-
- 抗原 See all SELPLG 抗体
- SELPLG (Selectin P Ligand (SELPLG))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This SELPLG antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Blocking Reagent (BR)
- 品牌
- BD Pharmingen™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- 免疫原
- PSGL-1 human IgG1 fusion protein
- 克隆位点
- 4RA10
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product SELPLG Primary Antibody
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anti-Selectin P Ligand (SELPLG) (AA 251-350) antibody
SELPLG 适用: 人 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Selectin P Ligand (SELPLG) antibody (PE)SELPLG 适用: 人 FACS 宿主: 小鼠 Monoclonal TC2 PE
anti-Selectin P Ligand (SELPLG) (AA 40-280) antibodySELPLG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Selectin P Ligand (SELPLG) (AA 94-345) antibodySELPLG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P Ligand (SELPLG) antibodySELPLG 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Selectin P Ligand (SELPLG) antibodySELPLG 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PSGL1-1601 unconjugated
anti-Selectin P Ligand (SELPLG) (N-Term) antibodySELPLG 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Selectin P Ligand (SELPLG) antibody (FITC)SELPLG 适用: 人 FACS 宿主: 小鼠 Monoclonal TC2 FITC
anti-Selectin P Ligand (SELPLG) antibody (APC)SELPLG 适用: 人 FACS 宿主: 小鼠 Monoclonal TC2 APC
anti-Selectin P Ligand (SELPLG) (N-Term) antibodySELPLG 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice." in: Circulation, Vol. 107, Issue 17, pp. 2244-9, (2003) (PubMed).
: "P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules." in: The Journal of experimental medicine, Vol. 197, Issue 10, pp. 1355-63, (2003) (PubMed).
: "P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow." in: The Journal of clinical investigation, Vol. 109, Issue 7, pp. 939-50, (2002) (PubMed).
: "P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 8, pp. 4307-13, (2002) (PubMed).
: "Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1." in: Blood, Vol. 99, Issue 3, pp. 946-56, (2002) (PubMed).
: "P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration." in: The Journal of experimental medicine, Vol. 192, Issue 11, pp. 1669-76, (2000) (PubMed).
: "P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo." in: The Journal of experimental medicine, Vol. 191, Issue 8, pp. 1413-22, (2000) (PubMed).
: "The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum." in: Blood, Vol. 90, Issue 5, pp. 1934-42, (1997) (PubMed).
: "P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin." in: The Journal of experimental medicine, Vol. 185, Issue 3, pp. 573-8, (1997) (PubMed).
: "P-selectin glycoprotein ligand-1 mediates rolling of mouse bone marrow-derived mast cells on P-selectin but not efficiently on E-selectin." in: European journal of immunology, Vol. 27, Issue 6, pp. 1339-45, (1997) (PubMed).
: "Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin." in: The Journal of biological chemistry, Vol. 271, Issue 6, pp. 3255-64, (1996) (PubMed).
: "Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor." in: Blood, Vol. 87, Issue 10, pp. 4176-86, (1996) (PubMed).
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: "Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice." in: Circulation, Vol. 107, Issue 17, pp. 2244-9, (2003) (PubMed).
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- 抗原
- SELPLG (Selectin P Ligand (SELPLG))
- 别名
- CD162 (SELPLG 产品)
- 别名
- CD162 antibody, CLA antibody, PSGL-1 antibody, PSGL1 antibody, SELPLG antibody, SELPG antibody, Psgl-1 antibody, Psgl1 antibody, Selp1 antibody, Selpl antibody, selectin P ligand antibody, selectin, platelet (p-selectin) ligand antibody, clasper antibody, SELPLG antibody, Selplg antibody, cla antibody
- 背景
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The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
Synonyms: PSGL-1
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