PDGFRB 抗体 (pTyr771) (PE)
(1 reference)Quick Overview for PDGFRB 抗体 (pTyr771) (PE) (ABIN1177135)
抗原
See all PDGFRB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr771
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品牌
- BD Phosflow™
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纯化方法
- Purified from tissue culture supernatant or ascites by affinity chromatography
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免疫原
- Phosphorylated Human PDGFRbeta Peptide
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亚型
- IgG1 kappa
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anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 33-133) antibody
PDGFRB 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 4C12 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 887-1106) antibodyPDGFRB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 981-1066) antibodyPDGFRB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 1-1106) antibodyPDGFRB 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 40-72) antibodyPDGFRB 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 33-133) antibodyPDGFRB 适用: 人, 小鼠 ELISA, FACS 宿主: 小鼠 Monoclonal 2G7B7 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) antibodyPDGFRB 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1G9 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 1-1106) antibodyPDGFRB 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) antibodyMicroarray verified PDGFRB 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB472367 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 718-767) antibodyPDGFRB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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样本量
- 20 μL
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor." in: Oncogene, Vol. 21, Issue 12, pp. 1870-5, (2002) (PubMed).
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: "SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor." in: Oncogene, Vol. 21, Issue 12, pp. 1870-5, (2002) (PubMed).
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- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
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背景
- Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin and exerts its effects by binding to the PDGF receptor (PDGFR), a transmembrane protein tyrosine kinase. PDGFR is composed of PDGFRalpha (CD140a) and/or PDGFRbeta (CD140b) polypeptides. Both PDGF and PDGFR consist of subunits that form homo- or heterodimers with varying specificities: PDGF-AA binds only to alphaalpha PDGFR, PDGF-AB binds to both alphaalpha and alphabeta PDGFR, and PDGF-BB binds to all three PDGFRs. Ligand binding induces dimerization and activation of the receptor. Upon activation, CD140b is phosphorylated at multiple tyrosine sites and, in turn, an intracellular phosphorylation cascade is initiated. PDGFR localizes primarily to membrane invaginations termed caveolae, compartments that are enriched in several of its downstream effectors, including phosphatidylinositol 3'-kinase, Src, and phospholipase C-gamma. The J23-1044 monoclonal antibody recognizes the phosphorylated tyrosine 771 (pY771) in the kinase insert domain of CD140b. pY771 interacts with GTPase-activating protein, a negative regulator of Ras, and weakly with Shc, which indirectly promotes the activation of Ras.
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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