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B-Cell Linker 抗体 (pTyr84) (Alexa Fluor 647)

Name: B-Cell Linker 抗体 (pTyr84) (Alexa Fluor 647)
SKU: ABIN1177037
Availability: OutOfStock

This anti-B-Cell Linker antibody is a 小鼠单克隆 antibody detecting B-Cell Linker in ICS. Suitable for 人和小鼠. This Primary Antibody has been cited in 2+ publications.

(2 references)

产品编号 ABIN1177037

发货至: 中国

Quick Overview for B-Cell Linker 抗体 (pTyr84) (Alexa Fluor 647) (ABIN1177037)

抗原

See all B-Cell Linker (BLNK) 抗体

B-Cell Linker (BLNK)

适用

人, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This B-Cell Linker antibody is conjugated to Alexa Fluor 647

应用范围

Intracellular Staining (ICS)

克隆位点

J117-1278

Discover our top product BLNK Primary Antibody

抗原表位
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pTyr84

品牌

BD Phosflow™

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Phosphorylated Human BLNK Peptide

亚型

IgG2b kappa
anti-B-Cell Linker (BLNK) antibody
BLNK 适用: 人, 小鼠 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5G9 unconjugated

anti-B-Cell Linker (BLNK) (AA 65-314) antibody
BLNK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) (C-Term) antibody
Verified BLNK 适用: 人 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) (AA 301-400) antibody
BLNK 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1D7 unconjugated

anti-B-Cell Linker (BLNK) (pTyr96) antibody
BLNK 适用: 人 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) (AA 41-337) antibody
BLNK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) (N-Term) antibody
BLNK 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) (pTyr96) antibody
BLNK 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) (pTyr84) antibody
BLNK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-B-Cell Linker (BLNK) antibody
BLNK 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

样本量

20 μL

限制

仅限研究用
状态

Liquid

缓冲液

Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
Pighi, Gu, Dalai, Barbi, Parolini, Bertolaso, Pedron, Parisi, Ren, Cecconi, Chilosi, Menestrina, Zamò: "Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling." in: Cellular oncology (Dordrecht), Vol. 34, Issue 2, pp. 141-53, (2011) (PubMed).

Espeli, Mancini, Breton, Poirier, Schiff: "Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions." in: Blood, Vol. 113, Issue 23, pp. 5878-86, (2009) (PubMed).
抗原

B-Cell Linker (BLNK)

别名

BLNK

背景

B cell activation is initiated by crosslinking the B cell receptor, which leads to activation of non-receptor protein tyrosine kinases (PTK), including Btk, Syk, and three Src kinases, Fyn, Lyn, and Blk. Activated PTKs then phosphorylate multiple cellular proteins involved in B lymphocyte signaling. Syk is responsible for the tyrosine phosphorylation of B cell linker protein (BLNK), a member of the SLP-76 family of adapter proteins. Phosphorylation of human BLNK at tyrosines 84, 178, and 189 (Y84, Y178, and Y189) creates docking sites for PLCg2, leading to the activation of downstream signaling pathways. The J117-1278 monoclonal antibody recognizes the phosphorylated Y84 of BLNK.

途径

BCR Signaling