IL-18 Receptor (Beta Chain) 抗体
This 大鼠 单克隆 antibody specifically detects IL-18 Receptor (Beta Chain) in Neut. It exhibits reactivity toward 小鼠. It has been mentioned in 8+ publications
(8 references)
产品编号 ABIN1177000
发货至:
中国
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Quick Overview for IL-18 Receptor (Beta Chain) 抗体 (ABIN1177000)
抗原
IL-18 Receptor (Beta Chain)
适用
小鼠
宿主
大鼠
克隆类型
单克隆
应用范围
Neutralization (Neut)
克隆位点
TC30-28E3
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产品特性
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Neutralization Activity: Assay Type: Proliferation at 50 pg/ml recombinant mouse IL-18 Indicator cell: 2D6 at 10^5 cells/well Preincubation of antibody and cells = 60 minutes
Activity Range: 50% Neutralization (ND50) at 0.2 - 10 µg/ml
>70% Neutralization at 10 - 100 µg/ml -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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过滤
- 0.2 μm filtered
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内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
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免疫原
- Mouse sIL-1R7 fusion protein
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亚型
- IgG2a lambda
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Interleukin-12 upregulates the IL-18Rbeta chain in BALB/c thymocytes." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 21, Issue 8, pp. 635-42, (2001) (PubMed).
: "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 4950-6, (2000) (PubMed).
: "Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5041-4, (1999) (PubMed).
: "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29445-50, (1998) (PubMed).
: "Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 8, pp. 3759-65, (1998) (PubMed).
: "Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells." in: The Journal of experimental medicine, Vol. 188, Issue 8, pp. 1485-92, (1998) (PubMed).
: "IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 7, pp. 3400-7, (1998) (PubMed).
: "Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity." in: Journal of leukocyte biology, Vol. 61, Issue 3, pp. 346-52, (1997) (PubMed).
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- IL-18 Receptor (Beta Chain)
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背景
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The TC30-28E3 antibody specifically binds to the beta subunit of the mouse Interleukin-18 Receptor complex (IL-18Rbeta). The mouse IL-18R complex is expressed by T cells stimulated with IL-12 alone or cultured with antigen and IL-12 to induce Th1 cells. IL-18R is constitutively expressed by NK cells. Resting mouse T cells and Th2 cells do not express detectable levels of IL-18R. The mouse IL-18R complex consists of the IL-18alpha chain, also known as IL-1 Receptor related protein 1 (IL-1Rrp1 or IL-R5) and the IL-18Rbeta chain also known as IL-1R accessory protein-like (IL-1RAcPL or IL-R7). The cell surface IL-18Ralpha chain binds IL-18 with low affinity. However its interaction with the IL-18Rbeta chain confers high affinity binding for the ligand. The IL-18Rbeta chain is not involved in ligand binding but is responsible for the transduction of biological signals. The immunogen used to generate the TC30-28E3 hybridoma was sIL-1R7 fusion protein.
Synonyms: IL-1RAcPL, IL-R7
抗原
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