(3 references)-
- 抗原 See all IFNGR1 抗体
- IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This IFNGR1 antibody is un-conjugated
-
应用范围
- ELISA, Flow Cytometry (FACS), Neutralization (Neut)
- 品牌
- BD Pharmingen™
- 产品特性
-
Neutralization Activity: This antibody has been reported to be useful for the neutralization of human IFN-gamma anti-viral activity. Neutralization may be measured with a encephalomyocarditis viral (EMCV) resistance assay using 600 pg/mL recombinant human IFN-gamma (Cat. No. 554617) with A549 indicator cells.
50% Neutralization (ND50) 0.2 - 2 µg/mL
> 90% Neutralization at 5 - 50 µg/mL - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- 免疫原
- Human IFN-gammaRalpha
- 克隆位点
- GIR
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product IFNGR1 Primary Antibody
-
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 270-489) antibody
IFNGR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibodyIFNGR1 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 5H1C9 unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 1-489) antibodyIFNGR1 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) antibodyKO Validated IFNGR1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (C-Term) antibodyIFNGR1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 431-480) antibodyIFNGR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibodyIFNGR1 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 1-489) antibodyIFNGR1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 181-193) antibodyVerified IFNGR1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) antibodyIFNGR1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
-
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
-
-
: "The IFN gamma receptor: a paradigm for cytokine receptor signaling." in: Annual review of immunology, Vol. 15, pp. 563-91, (1997) (PubMed).
: "Localization of IFN-gamma receptor in first trimester placenta to trophoblasts but lack of stimulation of HLA-DRA, -DRB, or invariant chain mRNA expression by IFN-gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 8, pp. 2675-80, (1992) (PubMed).
: "Generation and characterization of monoclonal antibodies specific for the human IFN-gamma receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 12, pp. 4231-7, (1988) (PubMed).
-
: "The IFN gamma receptor: a paradigm for cytokine receptor signaling." in: Annual review of immunology, Vol. 15, pp. 563-91, (1997) (PubMed).
-
- 抗原
- IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
- 别名
- CD119 (IFNGR1 产品)
- 别名
- CD119 antibody, IFNGR antibody, IFN-gammaR antibody, Ifgr antibody, Ifngr antibody, Nktar antibody, IFNGR1 antibody, MGC129098 antibody, ifngr1 antibody, MGC194858 antibody, MGC194873 antibody, zgc:194858 antibody, cd119 antibody, ifngr antibody, DKFZp469K1232 antibody, interferon gamma receptor 1 antibody, cytokine receptor family member B17 antibody, IFNGR1 antibody, Ifngr1 antibody, crfb17 antibody, ifngr1 antibody
- 背景
-
The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon-gamma receptor (IFN-gammaRalpha). The functionally active-form of the human IFN-gamma receptor consists of two (or more) subunits, with IFN-gammaRalpha responsible for IFN-gamma binding and both the IFN-gammaRalpha and beta chains required for the transduction of biologic responses. The IFN-gamma receptor alpha chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium. Binding of 125I-labeled GIR-208 antibody to IFN-gammaRalpha+ cells is reported to be specifically inhibited in the presence of excess IFN-gamma. GIR-208 does not cross react with IFN-gamma as tested by ELISA. The ability of this antibody to bind to IFN-gamma receptors of species other than human has not been determined. The immunogen used to generate this hybridoma was human IFN-gammaRalpha purified from human placenta. The GIR- 208 has been reported to block the binding of 125I-human IFN-gamma to IFN-gammaRalpha+ cells as well as purified, soluble human IFN-gammaRalpha. GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN-gamma on WISH cells in a dose-dependent fashion.
Synonyms: IFN-gamma Receptor alpha chain, IFNgammaRalpha - 途径
- Interferon-gamma Pathway
-
You are here:
