IFNGR1 抗体
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北京 101111
Quick Overview for IFNGR1 抗体 (ABIN1176897)
抗原
See all IFNGR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
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Neutralization Activity: This antibody has been reported to be useful for the neutralization of human IFN-gamma anti-viral activity. Neutralization may be measured with a encephalomyocarditis viral (EMCV) resistance assay using 600 pg/mL recombinant human IFN-gamma (Cat. No. 554617) with A549 indicator cells.
50% Neutralization (ND50) 0.2 - 2 µg/mL
> 90% Neutralization at 5 - 50 µg/mL -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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过滤
- 0.2 μm filtered
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内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
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免疫原
- Human IFN-gammaRalpha
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亚型
- IgG1 kappa
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anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibody
IFNGR1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3E1A9 unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 270-489) antibodyIFNGR1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibodyIFNGR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5H1C9 unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 1-489) antibodyIFNGR1 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) antibodyKO Validated IFNGR1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (C-Term) antibodyIFNGR1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 431-480) antibodyIFNGR1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 18-245) antibodyIFNGR1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) antibodyIFNGR1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Interferon gamma Receptor 1 (IFNGR1) (AA 181-193) antibodyVerified IFNGR1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "The IFN gamma receptor: a paradigm for cytokine receptor signaling." in: Annual review of immunology, Vol. 15, pp. 563-91, (1997) (PubMed).
: "Localization of IFN-gamma receptor in first trimester placenta to trophoblasts but lack of stimulation of HLA-DRA, -DRB, or invariant chain mRNA expression by IFN-gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 8, pp. 2675-80, (1992) (PubMed).
: "Generation and characterization of monoclonal antibodies specific for the human IFN-gamma receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 12, pp. 4231-7, (1988) (PubMed).
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: "The IFN gamma receptor: a paradigm for cytokine receptor signaling." in: Annual review of immunology, Vol. 15, pp. 563-91, (1997) (PubMed).
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- IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
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别名
- CD119
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背景
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The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon-gamma receptor (IFN-gammaRalpha). The functionally active-form of the human IFN-gamma receptor consists of two (or more) subunits, with IFN-gammaRalpha responsible for IFN-gamma binding and both the IFN-gammaRalpha and beta chains required for the transduction of biologic responses. The IFN-gamma receptor alpha chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium. Binding of 125I-labeled GIR-208 antibody to IFN-gammaRalpha+ cells is reported to be specifically inhibited in the presence of excess IFN-gamma. GIR-208 does not cross react with IFN-gamma as tested by ELISA. The ability of this antibody to bind to IFN-gamma receptors of species other than human has not been determined. The immunogen used to generate this hybridoma was human IFN-gammaRalpha purified from human placenta. The GIR- 208 has been reported to block the binding of 125I-human IFN-gamma to IFN-gammaRalpha+ cells as well as purified, soluble human IFN-gammaRalpha. GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN-gamma on WISH cells in a dose-dependent fashion.
Synonyms: IFN-gamma Receptor alpha chain, IFNgammaRalpha -
途径
- Interferon-gamma Pathway
抗原
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