ITGA4 抗体
(5 references)Our Local Distributor
北京 101111
Quick Overview for ITGA4 抗体 (ABIN1176851)
抗原
See all ITGA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
过滤
- 0.2 μm filtered
-
内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
-
免疫原
- AKR/Cum mouse spontaneous T lymphoma line TK1
-
亚型
- IgG2b kappa
-
-
anti-Integrin alpha 4 (ITGA4) (Internal Region) antibody
ITGA4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 5C4 unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 551-650) antibodyITGA4 适用: 人, 小鼠, 兔 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 833-977) antibodyITGA4 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 7E4C5 unconjugated
anti-Integrin alpha 4 (ITGA4) (C-Term) antibodyITGA4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) (AA 376-558) antibodyITGA4 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyKO Validated ITGA4 适用: 人 FACS, WB 宿主: 兔 Monoclonal 25GB2175 unconjugated Recombinant Antibody
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 适用: 人 FACS, WB, EIA 宿主: 小鼠 Monoclonal 5C4 unconjugated
anti-Integrin alpha 4 (ITGA4) antibodyITGA4 适用: 小鼠 FACS, IP, IHC (fro) 宿主: 大鼠 Monoclonal DATK32 unconjugated
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1.0 mg/mL
-
缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
-
储存液
- Azide free
-
储存条件
- 4 °C
-
储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
-
-
-
: "Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 12, pp. 6896-901, (1999) (PubMed).
: "Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response." in: European journal of immunology, Vol. 23, Issue 3, pp. 682-8, (1993) (PubMed).
: "Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 4, pp. 1172-82, (1993) (PubMed).
: "Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system." in: European journal of immunology, Vol. 21, Issue 10, pp. 2591-7, (1991) (PubMed).
: "Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha." in: Cell, Vol. 56, Issue 1, pp. 37-46, (1989) (PubMed).
-
: "Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 12, pp. 6896-901, (1999) (PubMed).
-
- ITGA4 (Integrin alpha 4 (ITGA4))
-
别名
- CD49d
-
背景
-
The R1-2 antibody reacts with the integrin alpha4 chain (CD49d), which is expressed as a heterdimer with either of two beta, beta1 or beta7 (also known as betap). The alpha4beta1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes, while the alpha4beta7 integrin (LPAM-1) is expressed on peripheral lymphocytes, but on only a small subset of thymocytes. These integrins mediate a variety of cell-cell and cell-matrix interactions, recognizing the ligands VCAM-1 (CD106) and fibronectin. There is evidence that levels of VLA-4 expression regulate the transendothelial migration of T lymphocytes into inflamed tissues. Integrin alpha4beta7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. The R1-2 antibody blocks some alpha4 integrin-mediated binding functions. In combination with mAb 9C10 (MFR4.B) (Cat. No. 553313), binding of VLA-4 expressing cells to VCAM-1 can be almost completely inhibited.
Synonyms: Integrin alpha4 chain -
途径
- Integrin Complex
抗原
-
