Integrin beta 7 Chain 抗体
This 大鼠 单克隆 antibody specifically detects Integrin beta 7 Chain in BR 和 FACS. It exhibits reactivity toward 人 和 小鼠. It has been mentioned in 6+ publications
(6 references)
产品编号 ABIN1176850
发货至:
中国
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Quick Overview for Integrin beta 7 Chain 抗体 (ABIN1176850)
抗原
Integrin beta 7 Chain
适用
人, 小鼠
宿主
大鼠
克隆类型
单克隆
应用范围
Blocking Reagent (BR), Flow Cytometry (FACS)
克隆位点
FIB27
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纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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过滤
- 0.2 μm filtered
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内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
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免疫原
- AKR/Cum mouse spontaneous T lymphoma cell line TK1
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亚型
- IgG2a kappa
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Identification of a binding site for integrin alphaEbeta7 in the N-terminal domain of E-cadherin." in: The Journal of biological chemistry, Vol. 271, Issue 48, pp. 30909-15, (1997) (PubMed).
: "Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1497-505, (1997) (PubMed).
: "Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 9, pp. 3847-61, (1994) (PubMed).
: "Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells." in: European journal of immunology, Vol. 24, Issue 3, pp. 635-40, (1994) (PubMed).
: "The mucosal T cell integrin alpha M290 beta 7 recognizes a ligand on mucosal epithelial cell lines." in: European journal of immunology, Vol. 23, Issue 7, pp. 1630-5, (1993) (PubMed).
: "Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system." in: European journal of immunology, Vol. 21, Issue 10, pp. 2591-7, (1991) (PubMed).
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- Integrin beta 7 Chain
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背景
- The FIB27 antibody reacts with the integrin beta7 chain (also known as integrin betap), which is found in association with either of two alpha chains. alpha4beta7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells, it interacts with several ligands, including VCAM-1, fibronectin, and MAdCAM-1. alphaIELbeta7 is found primarily on intestinal intraepithelial lymphocytes (IEL), and it may be involved in interactions between IEL and epithelia via recognition of E-cadherin. The FIB27 antibody blocks beta7 integrin-mediated adhesion to fibronectin, MAdCAM-1, and VCAM-1, and it cross-reacts with human integrin beta7.
抗原
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