IFIH1 抗体 (AA 78-555)
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北京 101111
Quick Overview for IFIH1 抗体 (AA 78-555) (ABIN1169453)
抗原
See all IFIH1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 78-555
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特异性
- Recognizes human MDA5.
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交叉反应
- 人
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human MDA5 (aa 78-555).
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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- IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))
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别名
- MDA5
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背景
- RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
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UniProt
- Q9BYX4
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途径
- Activation of Innate immune Response
抗原
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