Neutrophils 抗体
This anti-Neutrophils antibody is a 大鼠 单克隆 antibody detecting Neutrophils in FACS, IHC, Func 和 ICC. Suitable for 小鼠. This Primary Antibody has been cited in 8+ publications.
(8 references)Quick Overview for Neutrophils 抗体 (ABIN1169411)
抗原
Neutrophils
适用
小鼠
宿主
大鼠
克隆类型
单克隆
标记
This Neutrophils antibody is un-conjugated
应用范围
Flow Cytometry (FACS), Immunohistochemistry (IHC), Functional Studies (Func), Immunocytochemistry (ICC)
克隆位点
Nimp-R14
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特异性
- Recognizes mouse neutrophils (surface protein mouse Ly-6G) and may recognize Ly-6Chigh cells (inflammatory monocytes).
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交叉反应
- 小鼠
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
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免疫原
- Purified mouse BALB/c neutrophils.
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亚型
- IgG2b
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anti-Neutrophils antibody (PE)
适用: 小鼠 FACS 宿主: 大鼠 Monoclonal 07-04-14 PE
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Negative control: AG-35B-0011 http://www.adipogen.com/ag-35b-0011/rat-igg2b-isotype-control.html
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity." in: International journal of oncology, Vol. 53, Issue 4, pp. 1580-1590, (2018) (PubMed).
: "Rapid recruitment of inflammatory monocytes is independent of neutrophil migration." in: Blood, Vol. 102, Issue 1, pp. 328-35, (2003) (PubMed).
: "Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 7, pp. 3883-9, (2003) (PubMed).
: "An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 5, pp. 2628-36, (2000) (PubMed).
: "A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5." in: International immunology, Vol. 12, Issue 6, pp. 899-908, (2000) (PubMed).
: "Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4546-56, (1999) (PubMed).
: "Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice." in: Journal of leukocyte biology, Vol. 61, Issue 3, pp. 267-78, (1997) (PubMed).
: "Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies." in: British journal of haematology, Vol. 57, Issue 3, pp. 489-94, (1984) (PubMed).
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: "Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity." in: International journal of oncology, Vol. 53, Issue 4, pp. 1580-1590, (2018) (PubMed).
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- Neutrophils
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背景
- Neutrophils are key components of the inflammatory response and as such contribute to the killing of microorganisms. In addition, recent evidence suggests their involvement in the development of the immune response. The Nimp-R14 mAb displays features of an optimal reagent allowing the selective depletion of mouse neutrophils in vivo.
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UniProt
- P35461
抗原
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