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IL1RL1 抗体

This anti-IL1RL1 antibody is a 兔 多克隆 antibody detecting IL1RL1 in WB, ELISA 和 FACS. Suitable for 人.
产品编号 ABIN1169349
发货至: 中国

Quick Overview for IL1RL1 抗体 (ABIN1169349)

抗原

See all IL1RL1 抗体
IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

适用

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宿主

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克隆类型

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多克隆

标记

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This IL1RL1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • 特异性

    Recognizes soluble human ST2. Detects a band of ~50 kDa by Western blot and the endogenous ST2 by Flow Cytometry.

    交叉反应

    过滤

    0.2 μm filtered

    免疫原

    Recombinant human soluble ST2.
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    In PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.

    有效期

    6 months
  • 抗原

    IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

    别名

    ST2

    背景

    ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.

    UniProt

    Q01638
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