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AIM2 抗体 (AA 1-186)

Name: AIM2 抗体 (AA 1-186)
Brand: antibodies-online
SKU: ABIN1169341
Availability: OutOfStock

This anti-AIM2 antibody is a 小鼠单克隆 antibody detecting AIM2 in WB 和 ICC. Suitable for 人. This Primary Antibody has been cited in 3+ publications.

(3 references)

产品编号 ABIN1169341

发货至: 中国

Quick Overview for AIM2 抗体 (AA 1-186) (ABIN1169341)

抗原

See all AIM2 抗体

AIM2 (Absent in Melanoma 2 (AIM2))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This AIM2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunocytochemistry (ICC)

克隆位点

3B10

Discover our top product AIM2 Primary Antibody

抗原表位
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AA 1-186

特异性

Recognizes human AIM2.

交叉反应

人

纯化方法

Purified from concentrated hybridoma tissue culture supernatant.

纯度

>95 % (SDS-PAGE)

免疫原

Human AIM2 (aa 1-186).

亚型

IgG1
anti-Absent in Melanoma 2 (AIM2) (AA 1-195) antibody
AIM2 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3C4G11 unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 1-195) antibody
AIM2 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 7G12D1 unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 1-343) antibody
AIM2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 1-50) antibody
AIM2 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 81-326) antibody
AIM2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 1-343) antibody
AIM2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 1-343) antibody
AIM2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (Internal Region) antibody
AIM2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 1-260) antibody
AIM2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Absent in Melanoma 2 (AIM2) (AA 14-215) antibody
AIM2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

In PBS containing 10 % glycerol and 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

有效期

12 months
Hornung, Ablasser, Charrel-Dennis, Bauernfeind, Horvath, Caffrey, Latz, Fitzgerald: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, (2009) (PubMed).

Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: "AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA." in: Nature, Vol. 458, Issue 7237, pp. 509-13, (2009) (PubMed).

Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, (2004) (PubMed).
抗原

AIM2 (Absent in Melanoma 2 (AIM2))

别名

AIM2

背景

AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

UniProt

O14862

途径

Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome