ANGPTL4 抗体
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北京 101111
Quick Overview for ANGPTL4 抗体 (ABIN1169316)
抗原
See all ANGPTL4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-ANGPTL4 (human), mAb (Kairos-1)
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特异性
- Recognizes the fibrinogen-like domain (FLD) of human ANGPTL4. Detects a band of ~62 kDa and ~35 kDa by Western blot. Does not cross-react with other ANGPTL family proteins.
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交叉反应 （详细）
- Does not cross-react with other ANGPTL family proteins.
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产品特性
- Monoclonal Antibody. Recognizes the fibrinogen-like domain (FLD) of human ANGPTL4. Detects a band of ~62 kDa and ~35 kDa by Western blot. Does not cross-react with other ANGPTL family proteins. Isotype: Mouse IgG1kappa. Clone: Kairos-1. Applications: ELISA, IHC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
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过滤
- 0.2 μm filtered
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免疫原
- Recombinant human ANGPTL4.
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亚型
- IgG1 kappa
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anti-Angiopoietin-Like 4 (ANGPTL4) (AA 182-388) antibody
ANGPTL4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (AA 182-394) antibodyANGPTL4 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (AA 1-406) antibodyANGPTL4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (AA 138-167) antibodyANGPTL4 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18264 unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (AA 138-167) antibodyANGPTL4 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (AA 26-406) antibodyANGPTL4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (AA 1-406) antibodyANGPTL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) (C-Term) antibodyANGPTL4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) antibodyANGPTL4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 4 (ANGPTL4) antibodyANGPTL4 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.2μm-filtered solution in PBS, pH 7.4.
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储存液
- Without preservative
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 1 year after receipt when stored at -20°C.
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有效期
- 12 months
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- ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
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别名
- ANGPTL4
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背景
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Alternate Names/Synonyms: Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein
Product Description: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
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UniProt
- Q9BY76
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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