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ANGPTL4 抗体

This anti-ANGPTL4 antibody is a 兔 多克隆 antibody detecting ANGPTL4 in WB 和 ELISA. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN1169313
发货至: 中国

Quick Overview for ANGPTL4 抗体 (ABIN1169313)

抗原

See all ANGPTL4 抗体
ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

适用

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宿主

  • 84
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克隆类型

  • 87
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多克隆

标记

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This ANGPTL4 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
  • 特异性

    Recognizes human ANGPTL4. Detects a band of ~35 kDa and 62 kDa by Western blot.

    交叉反应

    过滤

    0.2 μm filtered

    免疫原

    Recombinant human ANGPTL4.
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

    储存液

    Without preservative

    储存条件

    4 °C,-20 °C

    储存方法

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.

    有效期

    6 months
  • Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: "Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors." in: Blood cells, molecules & diseases, Vol. 48, Issue 1, pp. 25-9, (2012) (PubMed).

  • 抗原

    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

    别名

    ANGPTL4

    背景

    ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

    UniProt

    Q9BY76

    途径

    Regulation of Lipid Metabolism by PPARalpha
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