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IL-33 抗体

This anti-IL-33 antibody is a 兔 多克隆 antibody detecting IL-33 in WB 和 ELISA. Suitable for 小鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN1169164
发货至: 中国

Quick Overview for IL-33 抗体 (ABIN1169164)

抗原

See all IL-33 (IL33) 抗体
IL-33 (IL33) (Interleukin 33 (IL33))

适用

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  • 1
小鼠

宿主

  • 107
  • 38
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  • 2
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克隆类型

  • 113
  • 42
多克隆

标记

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  • 1
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This IL-33 antibody is un-conjugated

应用范围

  • 109
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Western Blotting (WB), ELISA
  • 特异性

    Recognizes mouse IL-33. Detects a band of ~18 kDa by Western blot.

    交叉反应

    小鼠

    无交叉反应

    交叉反应 (详细)

    Does not cross-react with human IL-33.

    过滤

    0.2 μm filtered

    免疫原

    Recombinant mouse IL-33.
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

    储存液

    Without preservative

    储存条件

    4 °C,-20 °C

    储存方法

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.

    有效期

    6 months
  • Hayakawa, Hayakawa, Kume, Tominaga: "Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26369-80, (2007) (PubMed).

  • 抗原

    IL-33 (IL33) (Interleukin 33 (IL33))

    别名

    IL-33

    背景

    Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL33 is converted by CASP1 to a 18 kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

    UniProt

    Q8BVZ5

    途径

    Production of Molecular Mediator of Immune Response
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