ZBP1 抗体 (AA 1-411)
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北京 101111
Quick Overview for ZBP1 抗体 (AA 1-411) (ABIN1169142)
抗原
See all ZBP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-411
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特异性
- Recognizes human and mouse ZBP1.
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交叉反应
- 人, 小鼠
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纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant mouse ZBP1 (aa 1-411)
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亚型
- IgG2a
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anti-Z-DNA Binding Protein 1 (ZBP1) (AA 10-167) antibody
ZBP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (AA 2-100) antibodyZBP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (AA 144-193) antibodyZBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Z-DNA Binding Protein 1 (ZBP1) (C-Term) antibodyZBP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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: "Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)." in: Frontiers in cellular and infection microbiology, Vol. 10, pp. 237, (2020) (PubMed).
: "IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 4, pp. 1489-1495, (2019) (PubMed).
: "ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death." in: The Journal of experimental medicine, Vol. 214, Issue 8, pp. 2217-2229, (2017) (PubMed).
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: "Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)." in: Frontiers in cellular and infection microbiology, Vol. 10, pp. 237, (2020) (PubMed).
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- ZBP1 (Z-DNA Binding Protein 1 (ZBP1))
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别名
- ZBP1
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背景
- ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection.
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UniProt
- Q9H171
抗原
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