Fetuin A 抗体
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北京 101111
Quick Overview for Fetuin A 抗体 (ABIN115504)
抗原
See all Fetuin A (AHSG) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody reacts to Fetuin-A.
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纯化方法
- Immunoaffinity chromatography
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免疫原
- Human serum
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应用备注
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ELISA. Western Blot. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 0.1 mL of deionized water
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浓度
- 1.0 mg/mL
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缓冲液
- 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
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储存液
- Azide free
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.
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有效期
- 6 months
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- Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))
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别名
- alpha-2-HS-Glycoprotein
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背景
- Fetuin-A (AHSG), a 59 kDa glycoprotein, consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly sinthetized in liver . It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declines following infection, inflamatory and malignancy. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, frequent complication of many degenerative diseases. Low serum level of Fetuin-A is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin-A binds to transforming growth factor- beta and blocks TGFbeta binding to cell surface receptors.Synonyms: AHSG, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, FETUA, Fetuin A, PRO2743
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基因ID
- 197
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NCBI登录号
- NP_001613
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UniProt
- P02765
抗原
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