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FABP4 抗体 (N-Term)

FABP4 适用: 人 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN115503
发货至: 中国
  • 抗原 See all FABP4 抗体
    FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))
    抗原表位
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    N-Term
    适用
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    宿主
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    克隆类型
    • 118
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    多克隆
    标记
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    This FABP4 antibody is un-conjugated
    应用范围
    • 88
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    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    序列
    MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA
    特异性
    This antibody recognizes Adipocyte Fatty Acid Binding Protein (FABP4/AFABP).
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Immunoaffinity Chromatography.
    免疫原
    The immunization antigen (14.7 kDa) is a protein containing 131 AA of recombinant Human FABP4 and one extra AA, N-terminal Methionin (highlighted).
    Top Product
    Discover our top product FABP4 Primary Antibody
  • 应用备注
    Western Blot. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Add 0.05 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
    缓冲液
    0.05 M Phosphate buffer, 0.1 M NaCl, pH 7.2 without preservatives.
    储存液
    Without preservative
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
    有效期
    6 months
  • 抗原
    FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))
    别名
    FABP4 (FABP4 产品)
    别名
    A-FABP antibody, AFABP antibody, ALBP antibody, aP2 antibody, LOC100223994 antibody, FABP antibody, AP2 antibody, FABP3 antibody, FABP4 antibody, MGC84940 antibody, fabp4 antibody, 422/aP2 antibody, ALBP/Ap2 antibody, Ap2 antibody, Lbpl antibody, Albp antibody, fatty acid binding protein 4 antibody, fatty acid-binding protein, adipocyte antibody, fatty acid binding protein 4, adipocyte antibody, fatty acid binding protein 4, adipocyte L homeolog antibody, Fatty acid-binding protein, adipocyte antibody, adipocyte fatty acid-binding protein antibody, adipocyte fatty acid binding protein antibody, FABP4 antibody, LOC100223994 antibody, fabp4.L antibody, fabp4 antibody, Fabp4 antibody, LOC100732353 antibody, LOC100861279 antibody, LOC100057425 antibody, LOC395224 antibody
    背景
    Adipocyte fatty acid binding protein AFABP is a 15 kDa member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds (bile acids or retinoids) in an internal cavity. AFABP is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells . In mice, targeted mutations in AFABP provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from AFABP-deficient mice also have reduced fficiency of lipolysis in vitro and in vivo, and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated AFABP expression in macrophages upon differentiation and activation. In these cells, AFABP modulates inflammatory responses and cholesterol ester accumulation, and total or macrophage-specific AFABP deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for AFABP in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.Synonyms: A-FABP, Adipocyte lipid-binding protein, Fatty acid-binding protein 4
    基因ID
    2167
    NCBI登录号
    NP_001433
    UniProt
    P15090
    途径
    Brown Fat Cell Differentiation
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