Cardiotrophin 1 抗体
Quick Overview for Cardiotrophin 1 抗体 (ABIN115501)
抗原
See all Cardiotrophin 1 (CTF1) 抗体适用
宿主
克隆类型
标记
应用范围
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序列
- MRGSHHHHHH GSSRREGSLE DPQTDSSVSL LPHLEAKIRQ THSLAHLLTK YAEQLLQEYV QLQGDPFGLP SFSPPRLPVA GLSAPAPSHA GLPVHERLRL DAAALAALPP LLDAVCRRQA ELNPRAPRLL RRLEDAARQA RALGAAVEAL LAALGAANRG PRAEPPAATA SAASATGVFP AKVLGLRVCG LYREWLSRTE GDLGQLLPGG SA
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特异性
- This antibody recognizes Human Cardiotrophin-1. Other species not tested.
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纯化方法
- Immunoaffinity chromatography
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免疫原
- Recombinant Human Cardiotrophin-1.
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anti-Cardiotrophin 1 (CTF1) (AA 121-201) antibody
CTF1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) antibodyCTF1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB52510 unconjugated
anti-Cardiotrophin 1 (CTF1) (AA 1-201) antibodyCTF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (AA 166-194), (C-Term) antibodyCTF1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (AA 151-200) antibodyCTF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (N-Term) antibodyCTF1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (AA 1-201) antibodyCTF1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (N-Term) antibodyCTF1 适用: 人, 大鼠, 小鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (N-Term) antibodyCTF1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cardiotrophin 1 (CTF1) (AA 1-201) antibodyCTF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ELISA. Western Blot.
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限制
- 仅限研究用
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溶解方式
- Restore with 0.1 mL of deionized water. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
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浓度
- 1.0 mg/mL
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缓冲液
- 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE, None
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储存液
- Azide free
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months without detectable loss of activity.
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有效期
- 6 months
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- Cardiotrophin 1 (CTF1)
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别名
- Cardiotrophin-1
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背景
- Cardiotrophin-1 (CT-1) is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT-1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT-1activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes. CT-1 has also a neurotrophic function. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. CT-1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. CT-1 can induce expression of the protective heat shock proteins (hsps) in cardiac cells. Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide (BNP) and angiotensinogen mRNA. CT-1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction. Total 212 AA. MW: 22.5 kDa (calculated). N-Terminal His-tag, 12 extra AA (highlighted).Synonyms: CT-1, CTF1
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基因ID
- 1489
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NCBI登录号
- NP_001136016
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UniProt
- Q16619
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途径
- JAK/STAT Signaling
抗原
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