CDKN1C 抗体
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北京 101111
Quick Overview for CDKN1C 抗体 (ABIN114824)
抗原
See all CDKN1C 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody is specific to a protein of 57 kDa known as p57Kip2 a cell cycle regulatory mitotic inhibitor. It does not cross react with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and is negative regulator of cell proliferation.
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纯化方法
- Purified
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免疫原
- BALB/C mice were injected with mouse recombinant p57Kip2protein.
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亚型
- IgG2b
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anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibody
CDKN1C 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 8G5D5 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1F4A9 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人, 小鼠 WB, IHC 宿主: 兔 Monoclonal KIP2-7083R unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (AA 291-343) antibodyCDKN1C 适用: 人, 小鼠, 大鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (pThr310) antibodyCDKN1C 适用: 人 WB, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人, 小鼠 IF, IHC, FACS 宿主: 小鼠 Monoclonal SPM308 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal KP10 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (N-Term) antibodyCDKN1C 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (AA 1-100) antibodyCDKN1C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (AA 34-64), (N-Term) antibodyCDKN1C 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB19047 unconjugated
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应用备注
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Immunuprecipitation (Native). Immunohistochemistry on Paraffin Embedded Sections: 1/25-1/50 in an ABC method 30-60 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Colon carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))
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别名
- CDKN1C / KIP2
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背景
- P57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.Synonyms: Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57KIP2
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基因ID
- 1028
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NCBI登录号
- NP_000067
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UniProt
- P49918
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途径
- Cell Division Cycle, Dopaminergic Neurogenesis
抗原
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