ACP5 抗体
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北京 101111
Quick Overview for ACP5 抗体 (ABIN114707)
抗原
See all ACP5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The Anti Human TRAP 5 Antibody, Clone: TRAP-01 is a mouse monoclonal antibody against TRAP 5.
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纯化方法
- Affinity chromatography on protein G
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免疫原
- Recombinant human TRAP 5 expressed in Sf 9 cells.
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亚型
- IgG1
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应用备注
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Enzyme Immunoassay.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 1 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
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浓度
- 1.0 mg/mL
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缓冲液
- 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE, None
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储存液
- Azide free
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
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有效期
- 6 months
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- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
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别名
- ACP5 / TR-AP
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背景
- TRAP 5 (serum band 5 tartrate-resistant acid phosphatase, TRACP 5, EC 3.1.3.2) is a glycoprotein of 35-37 kDa. TRAP 5 belongs to the most abundant enzymes in osteoclasts. It is expressed in certain differentiated cells of the mononuclear phagocyte system, particularly osteoclasts and alveolar macrophages, where it takes an active part in bone resorption process. High blood levels of TRAP 5 are usually associated with active bone remodelling. Increased serum levels are observed during normal bone growth among healthy children. Elevated serum TRAP levels have been detected in diseases characterized by increased bone resorption, Pagets disease of the bone, hemodialysis, primary hyperparathyroidism, metastatic malignancies involving bone resorption, multiple myeloma and bilaterally ovariectomized women. Post-menopausal women have higher levels of serum than post-menopausal women on estrogen replacement therapy. Therefore specific determination of TRAP 5 activity can be essential for clinical assessment of bone metabolism.Synonyms: Acid phosphatase 5 tartrate resistant, TRAP5, TRAcP, Tartrate-resistant acid ATPase, Tartrate-resistant acid phosphatase type 5
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基因ID
- 54
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NCBI登录号
- NP_001104504
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UniProt
- P13686
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途径
- Transition Metal Ion Homeostasis
抗原
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