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Leptin Receptor 抗体 (Extracellular Domain)

Name: Leptin Receptor 抗体 (Extracellular Domain)
SKU: ABIN114694
Availability: OutOfStock

This anti-Leptin Receptor antibody is a 小鼠单克隆 antibody detecting Leptin Receptor in WB, IHC (fro) 和 EIA. Suitable for 人. This Primary Antibody has been cited in 1 publication.

(1 reference)

产品编号 ABIN114694

发货至: 中国

Datasheet as PDF

Quick Overview for Leptin Receptor 抗体 (Extracellular Domain) (ABIN114694)

抗原

See all Leptin Receptor (LEPR) 抗体

Leptin Receptor (LEPR)

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This Leptin Receptor antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

克隆位点

LPR-01

Discover our top product LEPR Primary Antibody

抗原表位
16

16

9

9

7

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5

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Extracellular Domain

纯化方法

Affinity chromatography on protein G

免疫原

NSO mouse myeloma cell line. DNA sequence including the extracellular domain of Leptin Receptor (amino acid residues 1 839) fused to the Fc region of human IgG (with IIEGR added at the amino terminus and 6 histidine residues added at the carboxy terminus).

亚型

IgG1
anti-Leptin Receptor (LEPR) (AA 901-1000) antibody
LEPR 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, FACS, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (AA 310-539) antibody
LEPR 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (AA 22-203) antibody
LEPR 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (AA 238-375) antibody
LEPR 适用: 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (Internal Region) antibody
Verified LEPR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) antibody
LEPR 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Leptin Receptor (LEPR) (AA 23-52) antibody
LEPR 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (AA 501-600) antibody
LEPR 适用: 人, 小鼠, 大鼠 WB, FACS, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (C-Term) antibody
LEPR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Leptin Receptor (LEPR) (AA 31-130) antibody
LEPR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H5 unconjugated

应用备注

ELISA. Western Blot.

限制

仅限研究用
溶解方式

Restore with 0.1 mL of deionized water

浓度

1.0 mg/mL

缓冲液

0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE

储存液

Azide free

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.

有效期

6 months
Shen, Chen, Wang, Wang, Zhong, Han, Ouyang: "[Polymorphisms of CYP3A5 Gene in Acute Leukemia Patients and Their Role in Chemotherapy and Prognosis.]" in: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 16, Issue 1, pp. 26-30, (2008) (PubMed).
抗原

Leptin Receptor (LEPR)

别名

CD295 / Leptin Receptor

背景

Leptin receptor (OB R) was identified as a leptin binding protein (Leptin, the product of the ob gene, is a single chain 16 kDa protein consisting of 146 amino acid residues.) OB R was found to be a member of the class I cytokine receptor family with a large extracellular domain comprising 816 amino acid residues. Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Alternate splicing from a single gene derives the six isoforms of the Leptin receptor. The soluble form of the Leptin receptor, OB R contains no intracellular motifs or transmembrane residues, thus it consists entirely of the extracellular ligand binding domain of the receptor. Long forms of OB-R transcripts were reported to be expressed predominantly in regions of the hypothalamus which provides evidence that Leptin receptor is important in body weight regulation. Expression of short forms of OB-R transcripts have been found in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bioactive Leptin by binding and delaying its clearance from circulation. Soluble Leptin receptor levels are indirectly proportional to adiposity and are increased in females versus males. Leptin receptor levels are highest in infants, decrease into adolescence, and remain relatively stable throughout adulthood. Soluble Leptin receptor is also found upregulated in patients with chronic heart failure, end-stage renal disease and anorexia.Synonyms: DB, HuB219, LEP-R, LEPR, OB receptor, OB-R, OBR

基因ID

9606

UniProt

P48357

途径

JAK/STAT Signaling, AMPK Signaling, Feeding Behaviour