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CDH6 抗体 (Extracellular Domain)

This anti-CDH6 antibody is a 小鼠 单克隆 antibody detecting CDH6 in WB, IHC (p), IHC (fro) 和 IF. Suitable for 人.
产品编号 ABIN112365
发货至: 中国

Quick Overview for CDH6 抗体 (Extracellular Domain) (ABIN112365)

抗原

See all CDH6 抗体
CDH6 (K-Cadherin (CDH6))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CDH6 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

克隆位点

2B6
  • 抗原表位

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    Extracellular Domain

    特异性

    Clone 2B6 recognizes the extracellular domain of Cadherin-6.

    交叉反应 (详细)

    Species reactivity (tested):Human, Rat.

    纯化方法

    Purified

    免疫原

    Affinity purified extracellular domain of human cadherin-6-GST fusion protein

    亚型

    IgG1
  • 应用备注

    Immunoblotting (1: 25 - 1: 250). Immunocytochemistry. Immunohistochemistry on frozen sections when using a PBS buffer containing 0.1 mMCaCl2 and 0.1 mM MgCl2. Recommended range is 1: 25 - 1: 50 for immunohistochemistry with avidin-biotinylatedhorseradish peroxidase complex (ABC) as detection reagent.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS, 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    CDH6 (K-Cadherin (CDH6))

    别名

    Cadherin-6

    背景

    Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.Synonyms: CDH6, Cadherin K, K-Cadherin, Kidney cadherin

    基因ID

    1004

    NCBI登录号

    NP_004923

    UniProt

    P55285

    途径

    Cell-Cell Junction Organization
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