Desmocollin 1 抗体
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- 抗原 See all Desmocollin 1 (DSC1) 抗体
- Desmocollin 1 (DSC1)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Desmocollin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 序列
- HQTLESVKGV GQGDTGRYAT DWQC
- 特异性
- Reacts with 111 kDa (form "a") and 103 kDa (form "b") polypeptides (Desmocollin 1 splice forms, both at pI 5.2) from Human epidermal desmosomes. Mab localizes Dsc1 present in - suprabasal layers of interfollicular epidermis - specific cell layers (e.g. in hair follicle root sheath) - Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus).
- 纯化方法
- Affinity Chromatography on Protein A
- 免疫原
- Synthetic peptide corresponding to sequence present within the intracellular part of Human Desmocollin 1
- 克隆位点
- Dsc-1-U100
- 亚型
- IgG1
- Top Product
- Discover our top product DSC1 Primary Antibody
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anti-Desmocollin 1 (DSC1) (AA 486-686) antibody
DSC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) (AA 480-690) antibodyDSC1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) antibodyDSC1 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) antibodyDSC1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) (AA 30-353) antibodyDSC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) (AA 135-340) antibodyDSC1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) (AA 480-690) antibodyDSC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Desmocollin 1 (DSC1) (AA 659-687), (C-Term) antibodyDSC1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB21405 unconjugated
anti-Desmocollin 1 (DSC1) (AA 659-687), (C-Term) antibodyDSC1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Imunoblotting. Immunohistochemistry on frozen sections: 1: 10, 1 h at RT or overnight at 2-8C,preincubation with 0.05 - 0.2 % Triton X-100, for 5-10 min, depending on tissue type, isrecommended, Without detergent pretreatment a cytoplasmic component mightcross-react (e. g. in fibroblasts). Immunohistochemistry on paraffin-embedded sections (after microwave treatment): 1: 10, 1h at RT or overnight at 2-8C, a slight crossreactivity with a lymphocyte subpopulation isabolished by mild trypsinization after the microwave step)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 溶解方式
- Restore in 1 mL dist. water.
- 缓冲液
- PBS buffer, pH 7.4 containing 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- Desmocollin 1 (DSC1)
- 别名
- Desmocollin-1 (DSC1 产品)
- 别名
- DSC1 antibody, CDHF1 antibody, DG2/DG3 antibody, DSC1b antibody, DG2DG3 antibody, dg3 antibody, Dsc1a antibody, Dsc1b antibody, desmocollin 1 antibody, DSC1 antibody, Dsc1 antibody
- 背景
- Desmocollin 1 is a component of intercellular desmosome junctions. It is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. It may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Desmocollin 1 is linked to the keratinization of epithelial tissues.Synonyms: CDHF1, Cadherin family member 1, DG2/DG3, DSC1, Desmosomal glycoprotein 2/3
- 基因ID
- 1823
- NCBI登录号
- NP_004939
- UniProt
- Q08554
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