LDLR 抗体
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北京 101111
Quick Overview for LDLR 抗体 (ABIN112187)
抗原
See all LDLR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Suitable for analysis of LDL Receptor function in patients with familial hypercholesterolemia. The antibody recognizes an epitope in the region of repeat #1 of the ligand binding region. Addition of 15 nM antibody results in inhibition of half-maximal LDL-binding (cf. Beisiegel et al. 1981). In Human normal fibroblasts the antibody detects the 160 kDa polypeptide (pI 4.3) and also in bovine adrenal gland (160 kDa, pI 4.6) of LDL receptors (Beisiegel et al. 1982).
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交叉反应 （详细）
- Species reactivity (tested):Human and Bovine.
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纯化方法
- Affinity Chromatography
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免疫原
- Purified Bovine adrenal cortex LDL Receptor
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亚型
- IgG2b
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anti-Low Density Lipoprotein Receptor (LDLR) (C-Term) antibody
KO Validated LDLR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 22-150) antibodyLDLR 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1B10H10 unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 781-860) antibodyLDLR 适用: 人, 小鼠, 大鼠, Hamster, 植物 WB, ELISA, FACS, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) antibodyLDLR 适用: 人 IHC, ELISA, FACS, IF 宿主: 兔 Monoclonal 2B10 unconjugated Recombinant Antibody
anti-Low Density Lipoprotein Receptor (LDLR) (AA 497-742) antibodyLDLR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 263-509) antibodyLDLR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 105-205) antibodyLDLR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5E7 unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 335-588) antibodyLDLR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 499-511) antibodyLDLR 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Low Density Lipoprotein Receptor (LDLR) (AA 391-419) antibodyLDLR 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB22886 unconjugated
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应用备注
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FACS. Immunoblotting (Western blotting). Immunofluorescence (1/10-1/50).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 1.0 mL distilled water.
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缓冲液
- Final solution contains PBS buffer, pH 7.4 with 0.5 % BSA as stabilizer
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注意事项
- This product is photosensitive and should be protected from light
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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- LDLR (Low Density Lipoprotein Receptor (LDLR))
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别名
- LDLR
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背景
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor
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基因ID
- 3949
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NCBI登录号
- NP_000518
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UniProt
- P01130
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途径
- Hepatitis C, Lipid Metabolism
抗原
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