Fibronectin 抗体
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北京 101111
Quick Overview for Fibronectin 抗体 (ABIN112024)
抗原
See all Fibronectin 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes Fibronectin specifically in connective tissues and vessels. No reactivity with the soluble dimeric form of Fibronectin (plasma Fibronectin), but highly reactive with matrix Fibronectin. Animal biodistribution experiments have shown that after intravenous administration, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
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纯化方法
- Protein A chromatography
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免疫原
- Native human fibronectin (matrix)
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亚型
- IgG1
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anti-Fibronectin (AA 1201-1300) antibody
适用: 人, 大鼠, 小鼠, Cow WB, ELISA, ICC, IHC (p), IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 355-558) antibody适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 2117-2236) antibody适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 313-607) antibody适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 1998-2106) antibody适用: 人 WB, IHC, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 2240-2280) antibody适用: 人, 大鼠, 小鼠 WB, IHC (p), IF (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Fibronectin (AA 355-558) antibody适用: 大鼠 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Fibronectin (AA 510-689) antibody适用: 小鸡 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin (AA 2206-2337) antibody适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin antibodyKD Validated 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
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Immunohistochemistry on frozen and paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- PBS, pH 7.2, 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C foor one month or (in aliquots) at -20 °C for longer.
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- Fibronectin
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背景
- Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).Synonyms: CIG, Cold-insoluble globulin, FN1
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基因ID
- 2335
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NCBI登录号
- NP_002017
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UniProt
- P02751
抗原
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