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CRH 抗体

CRH 适用: 人 IHC (p), EIA 宿主: 小鼠 Monoclonal 4H9 unconjugated
产品编号 ABIN111808
发货至: 中国
  • 抗原 See all CRH 抗体
    CRH (Corticotropin Releasing Hormone (CRH))
    适用
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    宿主
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    小鼠
    克隆类型
    • 91
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    单克隆
    标记
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    This CRH antibody is un-conjugated
    应用范围
    • 82
    • 36
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    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody is specific for corticotrophin releasing factor (CRF), a hormone found mainly in the hypothalamus that regulates the release of corticotrophin from the pituitary gland. The unique lysine residue (Lys-36) is likely to be involved in the antigenic determinant as lysine modification by CA blocks binding completely. Human serum, containing CRF-binding protein, also inhibits the binding of this antibody to CRF.Aff. Const.:10(e)-9 M with native and modified CRF
    纯化方法
    Affinity chromatography on Protein G
    免疫原
    Corticotrophin Releasing Factor conjugated to Bovine Serum Albumin.
    克隆位点
    4H9
    亚型
    IgG1
    Top Product
    Discover our top product CRH Primary Antibody
  • 应用备注
    Immunohistochemistry on Frozen sections. Immunohistochemistry on Paraffin sections: 1/100 - 1/7000, Microwave pretreatment isrequired. Enzyme digestion with 0.1 % trypsin may also be necessary. ELISA: This antibody is suitable for use in a sandwich ELISA with clone 5D5 (BM356).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS containing 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    CRH (Corticotropin Releasing Hormone (CRH))
    别名
    Corticoliberin (CRH 产品)
    别名
    CRF antibody, Gm1347 antibody, crf antibody, crh antibody, zgc:101864 antibody, CRH antibody, corticoliberin antibody, crhb antibody, crh.1-a antibody, crha antibody, corticotropin releasing hormone antibody, corticotropin releasing hormone b antibody, corticotropin releasing hormone S homeolog antibody, corticotropin releasing hormone L homeolog antibody, Crh antibody, CRH antibody, crhb antibody, crh antibody, crh.S antibody, crh.L antibody
    背景
    CRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few).Synonyms: CRF, CRH, Corticotropin-Releasing Factor, Corticotropin-Releasing Hormone
    基因ID
    1392
    NCBI登录号
    NP_000747
    UniProt
    P06850
    途径
    Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour
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