Tyrosine Hydroxylase 抗体
Quick Overview for Tyrosine Hydroxylase 抗体 (ABIN1112833)
抗原
See all Tyrosine Hydroxylase (TH) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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免疫原
- Purified rat TH.
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亚型
- IgG1
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应用备注
- WB (1:100-400), IHC-P (1:50-200), IHC-Fr (1:100-500). Other applications have not been tested. The optimal dilutions should be determined by end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- TBS (0.1M), 30% Glycerol and 0.01% Sodium Azide.
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.
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有效期
- 12 months
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- Tyrosine Hydroxylase (TH)
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别名
- Tyrosine Hydroxylase
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背景
- Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. It also can be inhibited by the drug alpha-methyl-para-tyrosine (metirosine). This drug is rarely used and can cause depression, but it is useful in treating pheochromocytoma and also resistant hypertension.
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途径
- Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour
抗原
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