Epithelial cell adhesion molecule (Ep-CAM) is a pan-epithelial differentiation antigen. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. It has been used as an immunotherapeutic target in the treatment of gastrointestinal, urological and other carcinomas. It is expressed in undifferentiated pluripotent stem cells. and it is being used as a target for immunotherapy treatment of human carcinomas.