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TUBB 抗体 (C-Term)

This anti-TUBB antibody is a 小鼠 单克隆 antibody detecting TUBB in WB 和 IF. Suitable for 小鼠, 大鼠, 猴, 犬 和 Hamster.
产品编号 ABIN1112713
发货至: 中国

Quick Overview for TUBB 抗体 (C-Term) (ABIN1112713)

抗原

See all TUBB 抗体
TUBB (Tubulin, beta (TUBB))

适用

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小鼠, 大鼠, 猴, 犬, Hamster

宿主

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  • 86
  • 2
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小鼠

克隆类型

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  • 91
  • 2
单克隆

标记

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This TUBB antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

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    C-Term

    特异性

    Detect the endogenous levels of total beta-Tubulin protein.

    免疫原

    Protein fragment on C-terminal of human beta-Tubulin.

    亚型

    IgG1
  • 应用备注

    Western Blot (1:5000), Immunofluorescence(1:1000) .Other applications have not been tested. The optimal dilutions should be determined by end user.

    限制

    仅限研究用
  • 状态

    Liquid

    储存液

    Sodium azide, Thimerosal (Merthiolate)

    储存条件

    -20 °C

    储存方法

    Store at -20 °C for 1 year. Avoid repeated freeze and thaw cycles.

    有效期

    12 months
  • 抗原

    TUBB (Tubulin, beta (TUBB))

    别名

    beta-Tubulin

    背景

    Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. 1 Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein. 2

    途径

    Microtubule Dynamics, M Phase
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