TUBB 抗体 (C-Term)
Quick Overview for TUBB 抗体 (C-Term) (ABIN1112713)
抗原
See all TUBB 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- Detect the endogenous levels of total beta-Tubulin protein.
-
免疫原
- Protein fragment on C-terminal of human beta-Tubulin.
-
亚型
- IgG1
-
-
-
-
应用备注
- Western Blot (1:5000), Immunofluorescence(1:1000) .Other applications have not been tested. The optimal dilutions should be determined by end user.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
储存液
- Sodium azide, Thimerosal (Merthiolate)
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C for 1 year. Avoid repeated freeze and thaw cycles.
-
有效期
- 12 months
-
-
- TUBB (Tubulin, beta (TUBB))
-
别名
- beta-Tubulin
-
背景
- Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. 1 Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein. 2
-
途径
- Microtubule Dynamics, M Phase
抗原
-