CHMP3 抗体
Quick Overview for CHMP3 抗体 (ABIN1109497)
抗原
See all CHMP3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Reacts with 25 kDa hVps24.
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交叉反应 （详细）
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Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Synthetic peptide derived from internal domain of Human Vps24 protein
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anti-Charged Multivesicular Body Protein 3 (CHMP3) (AA 28-61), (N-Term) antibody
CHMP3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51722 unconjugated
anti-Charged Multivesicular Body Protein 3 (CHMP3) (AA 28-77) antibodyCHMP3 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 3 (CHMP3) antibodyCHMP3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water.
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缓冲液
- 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))
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别名
- VPS24
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背景
- The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP3, also known as Vps24, associates directly with CHMP2 and CHMP4 for the disassembly of ESCRT-III complex in an ATP-dependent manner. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. Overexpression of CHMP3 strongly inhibits HIV-1 release. CHMP3 is expressed in brain, skeletal muscle, heart, lung, kidney and liver.Synonyms: CGI-149, CHMP3, Charged multivesicular body protein 3, Chromatin-modifying protein 3, NEDF, Neuroendocrine differentiation factor, Vacuolar protein-sorting-associated protein 24
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基因ID
- 51652
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NCBI登录号
- NP_001005753
抗原
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