TUBB3 抗体
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北京 101111
Quick Overview for TUBB3 抗体 (ABIN1109374)
抗原
See all TUBB3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Reacts with Human 55 kDa TUBB3 protein. Cross reacts with Mouse, Rat and other species.
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纯化方法
- Affinity Chromatography on Protein A
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water
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浓度
- 1 mg/mL
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缓冲液
- PBS, None
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- TUBB3 (Tubulin, beta 3 (TUBB3))
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别名
- TUBB3 / TUBB4
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背景
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha-chain. Tubulin is a highly conserved protein with a molecular weight of ~50 kD. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. The two main tubulin isoforms, α- and β-tubulin, are usually products of separate genes. The β-tubulin family includes six expressed genes that produce the polypeptide isoforms known as Classes I through VI, each of which have a distinct pattern of expression. Class III β-tubulin is found in neurons and mammalian testis cells and is widely used as a neuronal marker in developmental neurobiology, neoplasia, and stem cell research. Class III β-tubulin expression in neuronal and neuroblastic tumors is differentiation dependent, and its expression in certain non-neuronal neoplasms has been associated with poor prognosis and/or resistance to chemotherapy.Synonyms: Tubulin beta-3 chain, Tubulin beta-4, Tubulin beta-III
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基因ID
- 10381
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途径
- Microtubule Dynamics, M Phase
抗原
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