Optimal working dilution should be determined by the investigator.
限制
仅限研究用
溶解方式
Restore in distilled water.
缓冲液
0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None
注意事项
Avoid repeated freezing and thawing.
抗原
TRIB3
(Tribbles Homolog 3 (Drosophila) (TRIB3))
别名
TRIB3
背景
A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.Synonyms: NIPK, SKIP3, TRB-3, TRB3, Tribbles homolog 3