STXBP1 抗体 (C-Term, pThr574)
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Quick Overview for STXBP1 抗体 (C-Term, pThr574) (ABIN1109165)
抗原
See all STXBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term, pThr574
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特异性
- Reacts with Human 67 kDa Unc18-1 phosphorylated at Threonine 574.
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交叉反应 (详细)
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Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography on Protein A
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免疫原
- Synthetic peptide derived from C-terminal domain of Human STXBP1 protein containing Phosphorylated Thr574
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water.
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缓冲液
- 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- STXBP1 (Syntaxin Binding Protein 1 (STXBP1))
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别名
- STXBP1 / UNC18A
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背景
- Unc18-1, 2, and 3 (syntaxin binding proteins 1-3, STXBP1-3, UNC18-a-c, MUNC18-1-3) are chaperone molecules that block syntaxin interactions with cognate SNARE (soluble NSF attachment protein (SNAP) receptor) proteins and regulate exocytosis. Unc18-1-3 mRNA is present in RBL-2H3 mast cells, mouse bone marrow derived mast cells (BMMC), and platelets. Unc18-1 Ser-313 is a protein kinase C phosphorylation site and Thr-574 is a cyclin-dependent kinase 5 phosphorylation site that regulates Unc18-1/syntaxin1A interactions. Unc18-1 is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Unc18-2 colocalizes with syntaxin 3 at the apical plasma membrane of intestinal, proximal tubule, and collecting duct epithelial cells.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A
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基因ID
- 6812
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NCBI登录号
- NP_001027392
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途径
- Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
抗原
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