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STXBP1 抗体 (C-Term, pThr574)

The 兔 多克隆 anti-STXBP1 antibody is suitable to detect STXBP1 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC (fro) 和 EIA.
产品编号 ABIN1109165
发货至: 中国
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Quick Overview for STXBP1 抗体 (C-Term, pThr574) (ABIN1109165)

抗原

See all STXBP1 抗体
STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This STXBP1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
  • 抗原表位

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    C-Term, pThr574

    特异性

    Reacts with Human 67 kDa Unc18-1 phosphorylated at Threonine 574.

    交叉反应 (详细)

    Species reactivity (expected):Mouse, Rat.
    Species reactivity (tested):Human.

    纯化方法

    Affinity Chromatography on Protein A

    免疫原

    Synthetic peptide derived from C-terminal domain of Human STXBP1 protein containing Phosphorylated Thr574
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 溶解方式

    Restore in distilled water.

    缓冲液

    0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

    别名

    STXBP1 / UNC18A

    背景

    Unc18-1, 2, and 3 (syntaxin binding proteins 1-3, STXBP1-3, UNC18-a-c, MUNC18-1-3) are chaperone molecules that block syntaxin interactions with cognate SNARE (soluble NSF attachment protein (SNAP) receptor) proteins and regulate exocytosis. Unc18-1-3 mRNA is present in RBL-2H3 mast cells, mouse bone marrow derived mast cells (BMMC), and platelets. Unc18-1 Ser-313 is a protein kinase C phosphorylation site and Thr-574 is a cyclin-dependent kinase 5 phosphorylation site that regulates Unc18-1/syntaxin1A interactions. Unc18-1 is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Unc18-2 colocalizes with syntaxin 3 at the apical plasma membrane of intestinal, proximal tubule, and collecting duct epithelial cells.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

    基因ID

    6812

    NCBI登录号

    NP_001027392

    途径

    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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