Shiga-like Toxin (Stx) (Subunit A) 抗体
Stx
适用: E. coli
WB, EIA, Func
宿主: 小鼠
Monoclonal
1-10E-011
unconjugated
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- 抗原
- Shiga-like Toxin (Stx)
- 抗原表位
- Subunit A
- 适用
- E. coli
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宿主
- 小鼠
-
克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)
- 纯化方法
- Protein G purified
- 克隆位点
- 1-10E-011
- 亚型
- IgG1
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.1 % bovine serum albumin
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 2-8 °C.
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- 抗原
- Shiga-like Toxin (Stx)
- 背景
- Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-2 A subunit, SLT-2a, SLT-IIa, Verocytotoxin 2 subunit A, Verotoxin 2 subunit A, rRNA N-glycosidase 2, stx2A, stxA2
- 基因ID
- 10730
- UniProt
- P09385
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