Shiga-like Toxin (Stx) (Subunit A) 抗体
This anti-Shiga-like Toxin antibody is a 小鼠 单克隆 antibody detecting Shiga-like Toxin in WB, EIA 和 Func. Suitable for E. coli.
产品编号 ABIN1109002
发货至:
中国
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Quick Overview for Shiga-like Toxin (Stx) (Subunit A) 抗体 (ABIN1109002)
抗原
Shiga-like Toxin (Stx)
适用
E. coli
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)
克隆位点
1-10E-011
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抗原表位
- Subunit A
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纯化方法
- Protein G purified
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % bovine serum albumin
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储存条件
- 4 °C
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储存方法
- Product should be stored at 2-8 °C.
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- Shiga-like Toxin (Stx)
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背景
- Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11, and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. Antibodies to SLT-II can also neutralize a variant of SLT-II (designated SLT-Iiv) produced by strains of E.coli that cause edema. SLT-IIv is cytotoxic for Vero but not HeLa cells, distinguishing it from SLT-II. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-2 A subunit, SLT-2a, SLT-IIa, Verocytotoxin 2 subunit A, Verotoxin 2 subunit A, rRNA N-glycosidase 2, stx2A, stxA2
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基因ID
- 10730
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UniProt
- P09385
抗原
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