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SFTPD 抗体

SFTPD 适用: 人, 大鼠 WB, IHC (p), EIA, ELISA (Detection) 宿主: 小鼠 Monoclonal IVG8 unconjugated
产品编号 ABIN1108994
发货至: 中国
  • 抗原 See all SFTPD 抗体
    SFTPD (Surfactant Protein D (SFTPD))
    适用
    • 52
    • 21
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 大鼠
    宿主
    • 52
    • 17
    小鼠
    克隆类型
    • 52
    • 17
    单克隆
    标记
    • 33
    • 15
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SFTPD antibody is un-conjugated
    应用范围
    • 54
    • 32
    • 20
    • 10
    • 9
    • 8
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), ELISA (Detection)
    交叉反应 (详细)
    Species reactivity (tested):Human, rat
    纯化方法
    Protein G
    克隆位点
    IVG8
    亚型
    IgG1
    Top Product
    Discover our top product SFTPD Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2 - 8 °C.
  • 抗原
    SFTPD (Surfactant Protein D (SFTPD))
    别名
    SFTPD (SFTPD 产品)
    别名
    COLEC7 antibody, PSP-D antibody, SFTP4 antibody, SP-D antibody, BDE antibody, BDSD antibody, HOX4I antibody, SPD antibody, AI573415 antibody, Sftp4 antibody, surfactant protein D antibody, homeobox D13 antibody, surfactant associated protein D antibody, SFTPD antibody, HOXD13 antibody, Sftpd antibody, SP-D antibody
    背景
    SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages.Synonyms: COLEC7, Collectin-7, Lung surfactant protein D, PSP-D, PSPD, Pulmonary surfactant-associated protein D, SFTP4, SP-D
    基因ID
    10116
    UniProt
    P35248
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