This Mouse/Rabbit Monoclonal (304-1A5 & 31A5) cocktail antibody Recognizes Mammaglobin (10 kDa). When combined with other breast-restricted markers such as GCDFP-15, an overall sensitivity for breast carcinoma of 84 % has been achieved. Anti-Mammaglobin can also be used to determine breast origin in the setting of metastatic carcinoma. Cellular Localization: Cytoplasmic.
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
缓冲液
PBS, pH 7.4, 0.09 % Sodium Azide, 0.9 % BSA
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
抗原
Mammaglobin A (SCGB2A2)
(Secretoglobin, Family 2A, Member 2 (SCGB2A2))
背景
Mammaglobin, a member of the uteroglobin family, is a 10 kDa glycoprotein. Mammaglobin mRNA expression is breast tissue specific. It is overexpressed in human breast cancer. The use of Mammaglobin RT-PCR has been demonstrated to detect disseminated breast cancer. In a study to evaluate the frequency and specificity of mammaglobin, 80 % of all primary and metastatic breast tumors tested were immunopositive irrespective of tumor grade, while mammaglobin mRNA was detected in 60 % of the peripheral stem cell collections from breast cancer patients.Synonyms: MGB1, Mammaglobin-1, Mammaglobin-A, Prostatein peptide C3, Prostatic steroid-binding protein C3, Secretoglobin family 2A member 2, UGB2