SCD 抗体
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北京 101111
Quick Overview for SCD 抗体 (ABIN1108939)
抗原
See all SCD 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts to SCD / SCD1.
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纯化方法
- Affinity Purified
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免疫原
- Full length recombinant protein
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亚型
- IgG2b
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- PBS, pH 7.4 with 0.05 % sodium azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- SCD (Stearoyl-CoA Desaturase (Delta-9-Desaturase) (SCD))
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别名
- SCD / SCD1
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背景
- Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355aa, rat 358aa, ~37 KDa) is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. The SCD-1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD-1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders.Synonyms: Acyl-CoA desaturase, Delta(9)-desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase
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基因ID
- 6319
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NCBI登录号
- NP_005054
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UniProt
- O00767
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途径
- Brown Fat Cell Differentiation
抗原
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