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S100B 抗体

This anti-S100B antibody is a 小鼠 单克隆 antibody detecting S100B in WB, IF 和 IP. Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN1108929
发货至: 中国

Quick Overview for S100B 抗体 (ABIN1108929)

抗原

See all S100B 抗体
S100B (S100 Calcium Binding Protein B (S100B))

适用

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人, 大鼠, 小鼠

宿主

  • 137
  • 75
  • 10
  • 2
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  • 1
小鼠

克隆类型

  • 125
  • 102
单克隆

标记

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This S100B antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

克隆位点

SA-12
  • 特异性

    This antibody recognizes S100B.

    纯化方法

    Affinity chromatography

    免疫原

    Bovine brain S-100b.

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 溶解方式

    Restore with 1.2 % Sodium Acetate or neutral PBS

    浓度

    0.1 mg/mL

    缓冲液

    1.2 % Sodium Acetate with 2 mg BSA and 0.01 mg Sodium Azide as preservative.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    S100B (S100 Calcium Binding Protein B (S100B))

    别名

    S100B

    背景

    S100 calcium binding protein B or S100beta is a protein of the S-100 protein family. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 21q22.3. S100B is a glial-derived protein that is a well-established biomarker for severity of neurological injury and prognosis for recovery.1 S100 beta is a calcium-binding protein that is expressed at high levels in brain primarily by astrocytes. Addition of the disulfide-bonded dimeric form of S100 beta to primary neuronal and glial cultures and established cell lines induces axonal extension and alterations in astrocyte proliferation and phenotype, but evidence that S100 beta exerts the same effects in vivo has not been presented. Reeves et al. (1994) demonstrated that the same effects of the S100B protein are exerted in vivo. They found that both astrocytosis and neurite proliferation occurred in transgenic mice expressing elevated levels of S100b. They suggested that these transgenic mice represent a useful model for studies of the role of S100B in glial-neuronal interactions in normal development and function of the brain and for analyzing the significance of elevated levels of the protein in Down syndrome and Alzheimer disease.Synonyms: Astrocyte Marker, Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 beta, S100 calcium-binding protein B

    基因ID

    525716

    NCBI登录号

    NP_001029727

    UniProt

    P02638

    途径

    Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins
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