S100A12 抗体
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北京 101111
Quick Overview for S100A12 抗体 (ABIN1108920)
抗原
See all S100A12 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Reacts with 10 kDa Human S100A12 protein. No cross reaction with the other S100 protein family.
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纯化方法
- Affinity Chromatography on Protein A
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Restore in distilled water.
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缓冲液
- PBS, None
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- S100A12 (S100 Calcium Binding Protein A12 (S100A12))
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别名
- S100A12
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背景
- S100 family proteins are acidic low molecular weight proteins containing 2 EF-hand calcium binding domains. They are characterised by their cell-type specific expression patterns. S100A12 is a member of the calgranulin sub-family. Calgranulins are S100 proteins that are expressed by neutrophils and also found in infiltrating monocytes and granulocytes during chronic inflammation. S100A12 is expressed in neutrophils and monocytes. It is highly abundant in resting neutrophils, comprising 5 % of total cytostolic protein. S100A12 is a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.Synonyms: CAAF1, CAGC, CGRP, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, EN-RAGE, Extracellular newly identified RAGE-binding protein, Neutrophil S100 protein, S100 calcium-binding protein A12, S100-A12
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基因ID
- 6283
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途径
- Toll-Like Receptors Cascades, S100 Proteins
抗原
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