PTX3 抗体
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- 抗原 See all PTX3 抗体
- PTX3 (Pentraxin 3 (PTX3))
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适用
- 人
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This PTX3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
- 交叉反应 （详细）
- Species reactivity (tested):Human
- 纯化方法
- Protein G
- 免疫原
- Human recombinant PTX3
- 克隆位点
- MNB4
- 亚型
- IgG2a
- Top Product
- Discover our top product PTX3 Primary Antibody
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anti-Pentraxin 3 (PTX3) (AA 282-380) antibody
PTX3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-Pentraxin 3 (PTX3) (AA 151-250) antibodyPTX3 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (AA 99-164) antibodyPTX3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (AA 282-380) antibodyPTX3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B7 unconjugated
anti-Pentraxin 3 (PTX3) (N-Term) antibodyPTX3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (N-Term) antibodyPTX3 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (AA 183-381) antibodyPTX3 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (N-Term) antibodyPTX3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (AA 183-381) antibodyPTX3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pentraxin 3 (PTX3) (AA 195-381) antibodyPTX3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- PTX3 (Pentraxin 3 (PTX3))
- 别名
- PTX3 (PTX3 产品)
- 别名
- fb05a06 antibody, wu:fb05a06 antibody, TNFAIP5 antibody, TSG-14 antibody, PPTX antibody, AI607804 antibody, si:ch211-272f3.3 antibody, pentraxin 3 antibody, pentraxin related gene antibody, si:ch211-272f3.3 antibody, LOC100230343 antibody, PTX3 antibody, Ptx3 antibody
- 背景
- PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10 % of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modulation of complement activity by binding to C1q. Furthermore, PTX3 has been implicated in matrix deposition of cumulus cells. Moreover, PTX3 interacts with other biologically active molecules, causing their functional blockade. This has been demonstrated for fibroblast growth factor-2 (FGF-2), for which PTX3 acts as an inhibitor, leading to inhibition of angiogenesis. PTX3, like other pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP), binds apoptotic cells and debris. PTX3 is useful as an early indicator of myocyte irreversible injury in ischemic cardiomyopathy. PTX3 is not only involved in inflammatory vessel diseases related to atherosclerosis, but also in pre-eclampsia and systemic small vessel ANCA-associated vasulitis, in which neutrophils are key players. The relationship between tissue damage and pentraxin generation is stringent in acute injuries. PTX3 tunes self-non-self discrimination and tissue repair due to the recognition of diverse ligands by PTX3 and through regulation of effector pathways.Synonyms: Pentaxin-related protein PTX3, Pentraxin-related protein PTX3, TNF alpha-induced protein 5, TNFAIP5, TSG-14, TSG14, Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein
- 基因ID
- 9606
- UniProt
- P26022
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