This antibody detects Myelin Basic Protein at C-term. No cross reactivity with other proteins.
交叉反应 (详细)
Species reactivity (tested):Human, mouse, rat
纯化方法
Immunogen affinity purified
免疫原
Synthetic peptide corresponding to a sequence at the C-terminal of the human MBP .Remarks: Sequence is identical to the related rat and mouse sequence.
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
溶解方式
1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.
缓冲液
50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
抗原
MBP
(Myelin Basic Protein (MBP))
别名
Myelin Basic Protein
背景
Myelin basic protein (MBP) is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. It is most abundant in hemopoietic system and contains seven exons distributed over 32-34 kb. MBP isolated from MS brain may differ in charge microheterogeneity which would affect antigenic determinants. MBP is mapped to chromosome 18q22-23. Failure in this gene expression would be correlated in the central white matter with extrapyramidal system degeneration signs. Moreover, it is a candidate autoantigen in the disease multiple sclerosis.Synonyms: MBP, Myelin membrane encephalitogenic protein