Mbl1 抗体
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Quick Overview for Mbl1 抗体 (ABIN1108168)
抗原
See all Mbl1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Species reactivity (tested):Mouse
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纯化方法
- Protein G
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免疫原
- Purified mouse MBL-A
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亚型
- IgG
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anti-Mannose-Binding Lectin (Protein A) 1 (Mbl1) antibody
Mbl1 适用: 小鼠 WB, IF, IA, FACS 宿主: 大鼠 Monoclonal 8G6 unconjugated
anti-Mannose-Binding Lectin (Protein A) 1 (Mbl1) antibodyMbl1 适用: 小鼠 WB, IF, IHC (fx) 宿主: 大鼠 Monoclonal 8G6 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Mbl1 (Mannose-Binding Lectin (Protein A) 1 (Mbl1))
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别名
- MBL-A
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背景
- Mannose Binding Lectin (MBL), also called mannosebinding protein (MBP), is a calcium dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain enabling MBL to recognize carbohydrates (such as mannose and N-acetylglucosamine) on pathogens. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways, by using attached mannose binding lectin-associated serine proteases (MASP-2) in an antibody- and C1q-independent manner. MASP-2 permits cleavage of C4 and C2 to form a C3 convertase. Once it has bound, MBL exhibits complement-dependent antibacterial activities such as microbial opsonization and/or microbial lysis via membrane attack complexes and therefore plays an important role in innate immunity. In human, MBL is encoded by a single gene, whereas in mice there are two homologous proteins, termed MBL-A and MBL-C. The MBL-A concentration in serum is about 6-fold lower compared to that of MBL-C... MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. Moreover, it has been shown that MBL-A deficient mice have aberrant antigen-specific IgM responses and suffer from increased susceptibility to infection.
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基因ID
- 17194
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NCBI登录号
- NP_034905
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UniProt
- P39039
抗原
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